Mechanisms Underlying Allosteric Modulation of Antiseizure Medication Binding to Synaptic Vesicle Protein 2A (SV2A)
Anshumali Mittal, Matthew F. Martin, Laurent Provins, Adrian Hall, Marie Ledecq, Christian Wolff, Michel R. Gillard, Peter S. Horanyi, Jonathan A. Coleman
This paper reveals how UCB1244283 enhances BRV and LEV binding to SV2A by occupying an allosteric site, explaining its selectivity and potential for targeted therapeutics.
Proceedings of the National Academy of Sciences · Sep 2, 2025Peer-reviewedBiochemistry