Author

Anshumali Mittal

University of PittsburghORCID 0000-0002-0478-2682Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

Jonathan A. ColemaniD· 3 shared Matthew F. MartiniD· 3 shared Adrian HalliD· 2 shared Christian WolffiD· 2 shared Gary Wright MilleriD· 2 shared Laurent ProvinsiD· 2 shared Meghan L. BucheriD· 2 shared Michel R. GillardiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

Jonathan A. ColemanORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

NeurosciencebioRxivPreprintSep 22, 2026

Discovery of Selective Small-Molecule Ligands of SV2C by AI-Enhanced Virtual Screening and Experimental Validation

Alexander C. Brueckner, Matthew F. Martin, Sheenam Khuttan…·Gary Wright Miller

This paper identifies selective SV2C ligands using AI-enhanced virtual screening and experimental validation, finding 22 active molecules with high selectivity over SV2A and SV2B.

DOI 10.64898/2026.08.11.744237

machine learning (classical)drug response / drug discovery

𝕏 PostBluesky

BiochemistrybioRxivPreprintSep 13, 2026

Structural Determinants of Synaptic Vesicle Protein 2C Ligand Selectivity and Their Impact on Dopamine Release

Matthew F. Martin, Meghan L. Bucher, Se Joon Choi…·Jonathan A. Coleman

This study presents cryo-EM structures of SV2C and its ligands, revealing structural differences that explain ligand selectivity and impact dopamine release.

DOI 10.64898/2026.09.10.750697

mousecryo-EM

𝕏 PostBluesky

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedSep 2, 2025

Mechanisms Underlying Allosteric Modulation of Antiseizure Medication Binding to Synaptic Vesicle Protein 2A (SV2A)

Anshumali Mittal, Matthew F. Martin, Laurent Provins…·Jonathan A. Coleman

This paper reveals how UCB1244283 enhances BRV and LEV binding to SV2A by occupying an allosteric site, explaining its selectivity and potential for targeted therapeutics.

7 citations

experimental assayhost-pathogen & immune response

𝕏 PostBluesky