Author

Christian Wolff

UCB Pharma (Belgium)ORCID 0000-0003-0210-8608Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Assay:cryo-EM· 1 Assay:electronic health records· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Michel R. GillardiD· 3 shared Adrian HalliD· 2 shared Anshumali MittaliD· 2 shared Jonathan A. ColemaniD· 2 shared Laurent ProvinsiD· 2 shared Matthew F. MartiniD· 2 shared Peter S. HoranyiiD· 2 shared Amy E. Elder· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersBiochemistry

Michel R. GillardORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 13, 2026

Structural Determinants of Synaptic Vesicle Protein 2C Ligand Selectivity and Their Impact on Dopamine Release

Matthew F. Martin, Meghan L. Bucher, Se Joon Choi…·Jonathan A. Coleman

This study presents cryo-EM structures of SV2C and its ligands, revealing structural differences that explain ligand selectivity and impact dopamine release.

DOI 10.64898/2026.09.10.750697

mousecryo-EM

𝕏 PostBluesky

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedSep 2, 2025

Mechanisms Underlying Allosteric Modulation of Antiseizure Medication Binding to Synaptic Vesicle Protein 2A (SV2A)

Anshumali Mittal, Matthew F. Martin, Laurent Provins…·Jonathan A. Coleman

This paper reveals how UCB1244283 enhances BRV and LEV binding to SV2A by occupying an allosteric site, explaining its selectivity and potential for targeted therapeutics.

7 citations

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

NeurosciencebioRxivPreprintFeb 22, 2024

Discovery of novel compounds and target mechanisms using a high throughput, multiparametric phenotypic screen in a human neuronal model of Tuberous Sclerosis

Luis A. Williams, Steven J. Ryan, Vaibhav Joshi…·Graham T. Dempsey

The paper identifies chemical scaffolds that rescue functional TSC disease parameters through a phenotypic screen in a human neuronal model of Tuberous Sclerosis.

4 citations

humanelectronic health records

𝕏 PostBluesky