Jonathan A. Coleman

This paper identifies selective SV2C ligands using AI-enhanced virtual screening and experimental validation, finding 22 active molecules with high selectivity over SV2A and SV2B.

This study presents cryo-EM structures of SV2C and its ligands, revealing structural differences that explain ligand selectivity and impact dopamine release.

This paper reveals how UCB1244283 enhances BRV and LEV binding to SV2A by occupying an allosteric site, explaining its selectivity and potential for targeted therapeutics.

This study determines the structure of TGF-beta bound to betaglycan and its signaling receptors, revealing mechanisms of ligand selectivity and signal potentiation.

This study identifies VGLUT-mediated mechanisms protecting DA neurons from PD-related degeneration, revealing sex-specific effects and transcriptional regulators.