Lasso peptides sviceucin and siamycin I have anti-virulence activity and restore vancomycin effectiveness in vancomycin-resistant Enterococcus sp. and Staphylococcus aureus
Abdelhakim Boudrioua, Benjamin Baëtz, Solenn Desmadril, Christophe Goulard, Anne‐Claire Groo, Carine Lombard, Sabrina Butt‐Gueulle, Marie Marugan, Aurélie Malzert‐Fréon, Axel Hartke, Yanyan Li, Caroline Giraud
This study shows that lasso peptides sviceucin and siamycin I reduce virulence and restore vancomycin effectiveness against resistant bacteria by targeting histidine kinases.
iScience · Jan 30, 2025Peer-reviewedMicrobiology