Author

Marika Nespi

Genentech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Alicia A. Nugent· 1 shared Amber L. Cramer· 1 shared Anjani Ganti· 1 shared Anton Delwig· 1 shared Brett M. BabiniD· 1 shared Bryan Chan· 1 shared Casper C. HoogenraadiD· 1 shared Chang Hoon ChoiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Alicia A. Nugent

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1 paper

Recent·Most cited

SARM1 orthosteric base exchange inhibitors cause subinhibitory SARM1 activation

Rebecca Leahey, Martin Weber, Chang Hoon Cho, Seong Kwon Hur, Amber L. Cramer, Karla Manzanares, Brett M. Babin, Gladys de Leon Boenig, Taylor Kring, Liling Liu, Yusi Cui, Anjani Ganti, John P. Evans, Marika Nespi, Justin Ly, , Flora I. Hinz

The paper shows that subinhibitory concentrations of orthosteric SARM1 inhibitors can activate SARM1, leading to NAD consumption, neurodegeneration, and biomarker release in neurons.

bioRxiv · Aug 6, 2024 · PreprintNeuroscience