Brett M. Babin

A Two-Step Synthesis of Covalent Genetically-Encoded Libraries of Peptide-Derived Macrocycles (cGELs) enables use of electrophiles with diverse reactivity

This paper develops a two-step synthesis method for covalent genetically-encoded libraries of peptide-derived macrocycles (cGELs) that enables the use of electrophiles with diverse reactivity by controlling reaction conditions.

Rational design of potent small molecule SMARCA2/A4 (BRM/BRG1) degraders acting via the recruitment of FBXO22

This paper identifies a potent and specific SMARCA2/A4 degrader, G-6599, which works via FBXO22 recruitment and covalent conjugation, offering therapeutic potential.

SARM1 orthosteric base exchange inhibitors cause subinhibitory SARM1 activation

The paper shows that subinhibitory concentrations of orthosteric SARM1 inhibitors can activate SARM1, leading to NAD consumption, neurodegeneration, and biomarker release in neurons.

The dormancy-specific regulator, SutA, is intrinsically disordered and modulates transcription initiation in Pseudomonas aeruginosa

This paper investigates how SutA, a small protein in Pseudomonas aeruginosa, modulates transcription initiation during growth arrest by interacting with RNA polymerase.