Modeling statin-induced myopathy with human iPSCs reveals that impaired proteostasis underlies the myotoxicity and is targetable for the prevention
Xiaolin Zhao, Liyang Ni, Miharu Kubo, Mariko Matsuto, Hidetoshi Sakurai, Makoto Shimizu, Yu Takahashi, Ryuichiro Sato, Yoshio Yamauchi
This study uses human iPSC-derived myocytes to model statin-induced myopathy, showing statins impair proteostasis via the mevalonate pathway and identify FOXO1 as a target for prevention.
American Journal of Physiology-Cell Physiology · Mar 8, 2025Peer-reviewedPharmacology & Toxicology