Author

Hidetoshi Sakurai

Kyoto UniversityORCID 0000-0002-5383-9366Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 2 Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Liyang Ni· 2 shared Makoto ShimizuiD· 2 shared Ryuichiro SatoiD· 2 shared Xiaolin ZhaoiD· 2 shared Yoshio YamauchiiD· 2 shared Edward V. GenerozoviD· 1 shared Ekaterina A. SemenovaiD· 1 shared Gu Wenchao· 1 shared

Activity by Year

2021-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersPharmacology & Toxicology

Liyang Ni

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4 papers

Recent·Most cited

Selective induction by statins of FAM134B-mediated sarcoplasmic reticulum (SR)-phagy degrades the SR calcium pump SERCA1 and contributes to myopathy

Liyang Ni, Xiaolin Zhao, Lirong Zheng, Makoto Shimizu, Takashi Sasaki, Hidetoshi Sakurai, Ryuichiro Sato, Yoshio Yamauchi

This study identifies FAM134B-mediated SR-phagy as a mechanism by which statins induce myopathy by degrading SERCA1.

bioRxiv · Nov 26, 2025 · PreprintPharmacology & Toxicology

Large MAF Transcription Factors Reawaken Evolutionarily Dormant Fast-Glycolytic Type IIb Myofibers in Human Skeletal Muscle

Shunya Sadaki, Ryosuke Tsuji, Takuto Hayashi, Masato Watanabe, Ryoto Iwai, Gu Wenchao, Ekaterina A. Semenova, Султанов Ринат Илгизович, Желанкин Андрей Викторович, Edward V. Generozov, Ildus I. Ahmetov, Iori Sakakibara, Koichi Ojima, Hidetoshi Sakurai, Masafumi Muratani, , Ryo Fujita

This study identifies large MAF transcription factors as inducers of type IIb myofibers in humans, enhancing glycolytic capacity and correlating with power training.

Skeletal Muscle · Jul 26, 2025Peer-reviewedCell Biology

Modeling statin-induced myopathy with human iPSCs reveals that impaired proteostasis underlies the myotoxicity and is targetable for the prevention

Xiaolin Zhao, Liyang Ni, Miharu Kubo, Mariko Matsuto, Hidetoshi Sakurai, Makoto Shimizu, Yu Takahashi, Ryuichiro Sato, Yoshio Yamauchi

This study uses human iPSC-derived myocytes to model statin-induced myopathy, showing statins impair proteostasis via the mevalonate pathway and identify FOXO1 as a target for prevention.

American Journal of Physiology-Cell Physiology · Mar 8, 2025Peer-reviewedPharmacology & Toxicology

Nanopore direct RNA sequencing detects DUX4-activated repeats and isoforms in human muscle cells

Satomi Mitsuhashi, So Nakagawa, Mitsuru Sasaki‐Honda, Hidetoshi Sakurai, Martin C. Frith, Hiroaki Mitsuhashi

The paper uses nanopore direct RNA sequencing to analyze DUX4-induced gene expression and repetitive elements in human muscle cells, identifying new fusion transcripts and splicing events.

Human Molecular Genetics · Feb 24, 2021Peer-reviewedGenomics