Yoshio Yamauchi

This study identifies FAM134B-mediated SR-phagy as a mechanism by which statins induce myopathy by degrading SERCA1.

This study uses human iPSC-derived myocytes to model statin-induced myopathy, showing statins impair proteostasis via the mevalonate pathway and identify FOXO1 as a target for prevention.

This study identifies FGF21 as a key driver of denervation-induced skeletal muscle atrophy through HDAC4 regulation, showing that inhibiting FGF21 could mitigate muscle atrophy.

This study shows ABCA1 deficiency leads to tissue-specific SREBP2 pathway dysregulation in mice, depending on nutritional status, contributing to cholesterol deposition and atherosclerosis.