Author

Makoto Shimizu

The University of TokyoORCID 0000-0003-0467-9594Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Liyang Ni· 3 shared Ryuichiro SatoiD· 3 shared Yoshio YamauchiiD· 3 shared Hidetoshi SakuraiiD· 2 shared Lirong Zheng· 2 shared Xiaolin ZhaoiD· 2 shared Yu TakahashiiD· 2 shared Mariko Matsuto· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersPharmacology & Toxicology

Liyang Ni

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3 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintNov 26, 2025

Selective induction by statins of FAM134B-mediated sarcoplasmic reticulum (SR)-phagy degrades the SR calcium pump SERCA1 and contributes to myopathy

Liyang Ni, Xiaolin Zhao, Lirong Zheng…·Yoshio Yamauchi

This study identifies FAM134B-mediated SR-phagy as a mechanism by which statins induce myopathy by degrading SERCA1.

1 citation

𝕏 PostBluesky

Pharmacology & ToxicologyAmerican Journal of Physiology-Cell PhysiologyPeer-reviewedMar 8, 2025

Modeling statin-induced myopathy with human iPSCs reveals that impaired proteostasis underlies the myotoxicity and is targetable for the prevention

Xiaolin Zhao, Liyang Ni, Miharu Kubo…·Yoshio Yamauchi

This study uses human iPSC-derived myocytes to model statin-induced myopathy, showing statins impair proteostasis via the mevalonate pathway and identify FOXO1 as a target for prevention.

2 citations

humanexperimental assay

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BiochemistrybioRxivPreprintFeb 18, 2025

Fibroblast growth factor 21 regulates neuromuscular junctioninnervation through HDAC4 in denervation-induced skeletal muscle atrophy

Lirong Zheng, Takashi Sasaki, Liyang Ni…·Ryuichiro Sato

This study identifies FGF21 as a key driver of denervation-induced skeletal muscle atrophy through HDAC4 regulation, showing that inhibiting FGF21 could mitigate muscle atrophy.

DOI 10.1101/2025.02.18.638653

mousebulk RNA-seq

𝕏 PostBluesky