Context-dependent Interactors Regulate TDP-43 Dysfunction in ALS/FTLD
Longxin Xie, Yuehua Zhu, Bryan T. Hurtle, Matthew Wright, John L. Robinson, Jocelyn C. Mauna, Emily E. Brown, Marilyn Ngo, Cristian A Bergmann, Jiazhen Xu, Jessica Merjane, Amanda M. Gleixner, Gabriela Grigorean, Feilin Liu, Wilfried Rossoll, , Christopher J. Donnelly
The paper identifies context-dependent interactors of TDP-43 that regulate its dysfunction in ALS/FTLD using proximity labeling, mass spectrometry, and snRNA-seq integration.
bioRxiv · Apr 7, 2025 · PreprintMolecular Biology