Longxin Xie

Short UG-rich RNAs bind and stabilize TDP-43 RNA-recognition motifs to allosterically destabilize its prion-like domain helical region, preventing aggregation and mitigating neurodegeneration in cells and mice.

The paper identifies context-dependent interactors of TDP-43 that regulate its dysfunction in ALS/FTLD using proximity labeling, mass spectrometry, and snRNA-seq integration.

The paper introduces CUTS, a biosensor for real-time detection of TDP-43 loss-of-function, showing its sensitivity, accuracy, and potential for gene therapy applications.