Author

Bryan T. Hurtle

University of Pittsburgh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:snRNA-seq· 1

Frequent Co-Authors

Christopher J. DonnellyiD· 2 shared Cristian A BergmanniD· 2 shared Jessica MerjaneiD· 2 shared Longxin XieiD· 2 shared Amanda M. GleixneriD· 1 shared Charleen T Chu· 1 shared Edward B. LeeiD· 1 shared Emily E. Brown· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersMolecular Biology

Christopher J. DonnellyORCID

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2 papers

Recent·Most cited

Context-dependent Interactors Regulate TDP-43 Dysfunction in ALS/FTLD

Longxin Xie, Yuehua Zhu, Bryan T. Hurtle, Matthew Wright, John L. Robinson, Jocelyn C. Mauna, Emily E. Brown, Marilyn Ngo, Cristian A Bergmann, Jiazhen Xu, Jessica Merjane, Amanda M. Gleixner, Gabriela Grigorean, Feilin Liu, Wilfried Rossoll, , Christopher J. Donnelly

The paper identifies context-dependent interactors of TDP-43 that regulate its dysfunction in ALS/FTLD using proximity labeling, mass spectrometry, and snRNA-seq integration.

bioRxiv · Apr 7, 2025 · PreprintMolecular Biology

CUTS RNA Biosensor for the Real-Time Detection of TDP-43 Loss-of-Function

Longxin Xie, Jessica Merjane, Cristian A Bergmann, Jiazhen Xu, Shruthi Balasubramaniyan, Bryan T. Hurtle, Charleen T Chu, Christopher J. Donnelly

The paper introduces CUTS, a biosensor for real-time detection of TDP-43 loss-of-function, showing its sensitivity, accuracy, and potential for gene therapy applications.

bioRxiv · Jul 12, 2024 · PreprintMolecular Biology