Factor VIII exhibits chaperone-dependent and glucose-regulated reversible amyloid formation in the endoplasmic reticulum
Juthakorn Poothong, Anita Pottekat, Marina Siirin, Alexandre Rosa Campos, Adrienne W. Paton, James C. Paton, Jacqueline Lagunas-Acosta, Zhouji Chen, Mark F. Swift, Niels Volkmann, Dorit Hanein, Jing Yong, Randal J. Kaufman
This study identifies factors causing FVIII aggregation in the ER and shows that chaperones and glucose metabolism regulate its solubility and secretion.
Blood · Mar 3, 2020Peer-reviewedMolecular Biology