Cell BiologybioRxivPreprint
Divergent Retrograde Signaling Pathways Coordinate Longevity and Metformin Responses in Complex I and Complex IV Deficient C. elegans
Chutipong Chiamkunakorn, Juthakorn Poothong, Kongtana Trakarnsanga…·Wichit Suthammarak
This study shows that Complex I and Complex IV deficiencies in C. elegans activate distinct retrograde signaling pathways for longevity and metformin response, challenging the uniformity of mitohormesis.
DOI 10.64898/2026.09.15.751667