Dorit Hanein

Characterization of heterogeneity in nanodisc samples using Feret signatures

This paper introduces an in-silico method using Feret signatures to characterize nanodisc samples, enabling the identification of low-heterogeneity preparations for accurate structure determination of membrane proteins.

Factor VIII exhibits chaperone-dependent and glucose-regulated reversible amyloid formation in the endoplasmic reticulum

This study identifies factors causing FVIII aggregation in the ER and shows that chaperones and glucose metabolism regulate its solubility and secretion.

Electron cryo-tomography of vestibular hair-cell stereocilia

This paper develops a method to rapidly freeze unfixed stereocilia for 3D imaging, revealing structural features of stereocilia in a near-native state.