Substrate-induced clustering activates Trim-Away of pathogens and proteins
Jingwei Zeng, Ana Filipa Santos, Aamir S. Mukadam, Mariana Osswald, David A. Jacques, Claire F. Dickson, Stephen H. McLaughlin, Christopher M. Johnson, L. Kiss, Jakub Lupták, Nadine Renner, Marina Vaysburd, William A. McEwan, Eurico Morais‐de‐Sá, Dean Clift, Leo C. James
This study reveals how substrate-induced clustering activates TRIM21's ubiquitination activity for antiviral responses and protein degradation, introducing optogenetically controllable TRIM21-nanobody chimeras.
Nature Structural & Molecular Biology · Feb 25, 2021Peer-reviewedMolecular Biology