Author

Nadine Renner

MRC Laboratory of Molecular Biology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein design· 1 Assay:protein structure· 1

Frequent Co-Authors

Leo C. JamesiD· 3 shared David A. JacquesiD· 2 shared Aamir S. MukadamiD· 1 shared Alex B. KleinpeteriD· 1 shared Ana Filipa SantosiD· 1 shared Anna AlbeckaiD· 1 shared Boglarka VamosiD· 1 shared Christopher M. JohnsoniD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

Leo C. JamesORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The central pore of HIV-1 capsomers promotes sustained stability of the viral capsid

Alex B. Kleinpeter, Donna L. Mallery, Anna Albecka, Ryan C. Burdick, Nadine Renner, J. Ole Klarhof, Boglarka Vamos, Vinay K. Pathak, Leo C. James, Eric O. Freed

This study shows that the central pore of HIV-1 capsomers, mediated by R18 and K25 rings, is critical for capsid stability and post-entry events, with the N21K mutation compensating for R18 loss.

Journal of Molecular Biology · Jul 17, 2026Peer-reviewedMicrobiology

Mechanistic Insights into Lenacapavir-Induced Off-Pathway HIV-1 Capsid Assembly

Manish Gupta, Curt Waltmann, Nadine Renner, Yihang Wang, Leo C. James, David A. Jacques, Till Böcking, Gregory A. Voth

This study uses molecular simulations to show that lenacapavir disrupts HIV-1 capsid assembly by altering hexamer/pentamer ratios and impairing RNA encapsidation.

Proceedings of the National Academy of Sciences · Mar 10, 2026Peer-reviewedBiophysics

Substrate-induced clustering activates Trim-Away of pathogens and proteins

Jingwei Zeng, Ana Filipa Santos, Aamir S. Mukadam, Mariana Osswald, David A. Jacques, Claire F. Dickson, Stephen H. McLaughlin, Christopher M. Johnson, L. Kiss, Jakub Lupták, Nadine Renner, Marina Vaysburd, William A. McEwan, Eurico Morais‐de‐Sá, Dean Clift, Leo C. James

This study reveals how substrate-induced clustering activates TRIM21's ubiquitination activity for antiviral responses and protein degradation, introducing optogenetically controllable TRIM21-nanobody chimeras.

Nature Structural & Molecular Biology · Feb 25, 2021Peer-reviewedMolecular Biology