Intragenic recruitment of NF-κB drives alternative splicing modifications upon activation by the viral oncogene TAX of HTLV-1.
Lamya Ben Ameur, Paul Marie, Morgan Thénoz, Guillaume Giraud, Emmanuel Combe, Jean‐Baptiste Claude, Sébastien Lemaire, Nicolas Fontrodona, Hélène Polvèche, Marine Bastien, Antoine Gessain A, Eric Wattel, Cyril F. Bourgeois, Didier Auboeuf, Franck Mortreux
The paper shows that NF-κB recruitment to gene bodies via TAX activates alternative splicing through DDX17, affecting oncogenic pathways in HTLV-1 infection.
Nature Communications · Jun 16, 2020Peer-reviewedMolecular Biology