Cyril F. Bourgeois

The AMPK-related kinase NUAK1 regulates neuronal morphogenesis through the RNA splicing co-factor SON

This study identifies NUAK1 as a regulator of alternative splicing in cortical neurons through phosphorylation of SON, linking it to neurodevelopmental processes and ZTTK syndrome.

DDX5 and DDX17 RNA helicases regulate hepatitis B virus RNA splicing

This study shows DDX5 and DDX17 regulate HBV RNA splicing, affecting viral protein expression and liver disease progression.

Bolero: a dedicated workflow to decipher Hepatitis B virus transcriptome from long-reads sequencing method coupled to 5RACE amplification of transcripts

Bolero is a computational workflow for analyzing HBV long-read sequencing data to quantify viral RNA transcripts and spliced variants, enabling study of cccDNA transcriptional activity.

The MYCN oncoprotein and helicases DDX17 and DDX5 have opposite effects on the production of chimeric transcripts in neuroblastoma cells

This study shows that MYCN and helicases DDX17/DDX5 have opposing roles in transcription termination and chimeric transcript production in neuroblastoma, with MYCN inhibiting helicase activity and promoting harmful RNA molecules.

Helicases DDX5 and DDX17 promote Hepatitis B Virus transcription termination heterogeneity in infected human hepatocytes

The paper identifies DDX5 and DDX17 as factors promoting HBV transcriptional readthrough and affecting viral RNA stability and replication.

Gene-to-Gene Coordinated Regulation of Transcription and Alternative splicing by 3D Chromatin Remodeling upon NF-κB activation

This study investigates how NF-κB activation through HTLV-1 Tax reorganizes 3D chromatin to coordinate transcription and alternative splicing of target genes.

Monoallelic de novo variants in DDX17 cause a novel neurodevelopmental disorder

The paper identifies de novo monoallelic DDX17 variants in 11 patients with neurodevelopmental disorders and shows DDX17 dysfunction causes neuronal migration and axon outgrowth defects in multiple models.

SplicingLore: a web resource for studying the regulation of cassette exons by human splicing factors

SplicingLore provides a database of alternative exons regulated by 75 splicing factors, enabling analysis of splicing factor interactions and exon regulation.

Intragenic recruitment of NF-κB drives alternative splicing modifications upon activation by the viral oncogene TAX of HTLV-1.

The paper shows that NF-κB recruitment to gene bodies via TAX activates alternative splicing through DDX17, affecting oncogenic pathways in HTLV-1 infection.

Interplay between coding and exonic splicing regulatory sequences

The paper shows that exons regulated by the same splicing factor share similar nucleotide composition and code for amino acids with similar physicochemical properties.

Interplay between gene nucleotide composition bias and splicing

The paper identifies GC-rich and AT-rich exons with distinct splicing factor dependencies and shows how nucleotide composition bias influences chromatin organization and exon recognition during splicing.