Guillaume Giraud

This study shows DDX5 and DDX17 regulate HBV RNA splicing, affecting viral protein expression and liver disease progression.

Bolero is a computational workflow for analyzing HBV long-read sequencing data to quantify viral RNA transcripts and spliced variants, enabling study of cccDNA transcriptional activity.

The paper identifies DDX5 and DDX17 as factors promoting HBV transcriptional readthrough and affecting viral RNA stability and replication.

The paper shows that NF-κB recruitment to gene bodies via TAX activates alternative splicing through DDX17, affecting oncogenic pathways in HTLV-1 infection.