Sébastien Lemaire

This study shows that CENP-A, a centromeric histone variant, epigenetically regulates epithelial-mesenchymal plasticity and heterogeneity in human cells through non-centromeric mechanisms.

The paper shows ASF1 regulates replicative histone RNA metabolism by affecting RNA processing and stability, ensuring proper histone dosage during DNA replication.

The paper shows that NF-κB recruitment to gene bodies via TAX activates alternative splicing through DDX17, affecting oncogenic pathways in HTLV-1 infection.

The paper shows that exons regulated by the same splicing factor share similar nucleotide composition and code for amino acids with similar physicochemical properties.

The paper identifies GC-rich and AT-rich exons with distinct splicing factor dependencies and shows how nucleotide composition bias influences chromatin organization and exon recognition during splicing.