Large-scale discovery, analysis, and design of protein energy landscapes
A. Ferrari, Sugyan M. Dixit, Jane Thibeault, Mario T. García, Scott Houliston, R W Ludwig, Pascal Notin, Claire M. Phoumyvong, Cydney M. Martell, Michelle D. Jung, Kotaro Tsuboyama, Lauren P. Carter, C.H. Arrowsmith, Miklós Guttman, Gabriel J. Rocklin
The paper measures conformational fluctuations of protein domains using hydrogen-deuterium exchange mass spectrometry and uses computational modeling to design mutations that stabilize low-stability segments.
Nature · May 13, 2026Peer-reviewedBiophysics