Antagonistic Roles for MITF and TFE3 in Melanoma Plasticity
Jeremy Chang, Katelyn R. Campbell-Hanson, Marion Vanneste, Nicholas I. Bartschat, R. H. Nagel, Asdis K Arnadottir, Hong Nhung Vu, Collin Montgomery, Julius I. Yevdash, Jiarui Jiang, Ardith Bhinu, Annika Helverson, Michael D. Henry, Eirı́kur Steingrı́msson, Ronald J. Weigel, , Colin Kenny
This study identifies TFE3 and the non-canonical mTORC1 pathway as regulators of melanoma cell state plasticity, showing MITF suppresses the mesenchymal phenotype by modulating TFE3 expression.
Cell Reports · Mar 26, 2025Peer-reviewedCancer Biology