Deficiency of m6A RNA methylation promotes ZBP1-mediated cell death
Shuang Li, Xiangyu Deng, Deepak Pathak, Rashmi Basavaraj, Lina Sun, Yating Cheng, Jianrong Li, Marissa Burke, Gavin Wayne Britz, Chao Cheng, Yang Gao, Yi‐Lan Weng
The paper shows that m6A deficiency leads to 7SK RNA activation of the RIG-I/MAVS axis and ZBP1-mediated necroptotic cell death through IFN and rG4 synergies.
bioRxiv · Jun 29, 2024 · PreprintMolecular Biology