Ashwin and FAM98 paralogs define nuclear and cytoplasmic RNA ligase complexes for tRNA biogenesis and the unfolded protein response
Moritz Leitner, Marius Moser, Nathan Raynaud, Moritz M. Pfleiderer, Martin Jínek, Javier Martinez
This paper identifies Ashwin as a nuclear import factor for the tRNA ligase complex and shows that FAM98 paralogs determine its subcellular localization for tRNA biogenesis and UPR.
bioRxiv · Aug 1, 2025 · PreprintCell Biology