Author
Max Perutz LabsORCID 0000-0001-9152-7323Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Sebastian Guzman-Perez, Moritz Kleinwaechter, Muhammet Samet Ozeren…·Igor Asanović
This study identifies how PYROXD1 myopathy-causing variants impair RNA ligation by affecting RTCB activation and protein stability.
Moritz M. Pfleiderer, Moritz Kleinwächter, Ajse S. Nievergelt…·Martin Jínek
This study determines the atomic structure of the human tRNA-ligase complex and reveals its assembly mechanism and functional implications.
Moritz Leitner, Marius Moser, Nathan Raynaud…·Javier Martinez
This paper identifies Ashwin as a nuclear import factor for the tRNA ligase complex and shows that FAM98 paralogs determine its subcellular localization for tRNA biogenesis and UPR.
Anna Köferle, Andreas Schlattl, Alexandra Hörmann…·Ralph A. Neumüller
The paper identifies novel paralog gene dependencies in cancer, including sex chromosome-encoded gene pairs, suggesting therapeutic strategies for tumors with Y-chromosome loss.