Author

Moritz M. Pfleiderer

University of ZurichORCID 0000-0002-2369-5824Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Javier MartineziD· 2 shared Martin JínekiD· 2 shared Moritz KleinwächteriD· 2 shared Ajse S. NievergeltiD· 1 shared Alena KroupovaiD· 1 shared F. BonebergiD· 1 shared Marius Moser· 1 shared Nathan RaynaudiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 22 mutual co-author links

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2 shared papersBiochemistry

Javier MartinezORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedSep 17, 2026

Structural framework for the assembly of the human tRNA ligase complex

Moritz M. Pfleiderer, Moritz Kleinwächter, Ajse S. Nievergelt…·Martin Jínek

This study determines the atomic structure of the human tRNA-ligase complex and reveals its assembly mechanism and functional implications.

2 citations

humanstructural biology

𝕏 PostBluesky

Cell BiologybioRxivPreprintAug 1, 2025

Ashwin and FAM98 paralogs define nuclear and cytoplasmic RNA ligase complexes for tRNA biogenesis and the unfolded protein response

Moritz Leitner, Marius Moser, Nathan Raynaud…·Javier Martinez

This paper identifies Ashwin as a nuclear import factor for the tRNA ligase complex and shows that FAM98 paralogs determine its subcellular localization for tRNA biogenesis and UPR.

3 citations

humanproteomics

𝕏 PostBluesky