IL1β/IL1R1/IRAK4 Drives Inflammatory Ovarian Cancer Seeding at the inflamed sites and Is Reversed by an IRAK4 inhibitor UR241-2
J. Miller, Kyukwang Kim, Cameron W. A. Snyder, Negar Khazan, Niloy A. Singh, Megan E. Boyer, Elizabeth A. LaMere, Myla Strawderman, Sonali Sharma, Ronald Lakony, Michelle Whittum, Mark Anderson, Rick Keenan, Elizabeth Pritchett, Cameron Baker, , Rakesh K. Singh
This paper identifies the IL1β/IL1R1/IRAK4 axis as critical for inflammation-driven ovarian cancer metastasis and shows that IRAK4 inhibition with UR241-2 reduces tumor seeding and activates antitumor immune responses.
bioRxiv · May 5, 2026 · PreprintCancer Biology