MYBPC3 D389V Variant Induces Hypercontractility in Cardiac Organoids
Darshini A. Desai, Taejeong Song, Rohit R. Singh, Akhil Baby, James W. McNamara, Lisa C. Green, Pooneh Nabavizadeh, Mark B. Ericksen, Sholeh Bazrafshan, Sankar Natesan, Sakthivel Sadayappan
This study investigates the molecular mechanisms of HCM caused by the MYBPC3 D389V variant using cardiac organoids and shows hypercontractility and mitochondrial defects that are rescued by a myosin inhibitor.
Cells · Nov 19, 2024Peer-reviewedCell Biology