Sankar Natesan

This study investigates the role of fast Myosin Binding Protein-C (fMyBP-C) in skeletal muscle homeostasis across age and disease states using mouse models, finding it critical for muscle function and showing its potential as a therapeutic target.

This study investigates the molecular mechanisms of HCM caused by the MYBPC3 D389V variant using cardiac organoids and shows hypercontractility and mitochondrial defects that are rescued by a myosin inhibitor.