Author

Rohit R. Singh

Amgen (United States)ORCID 0000-0002-7282-2025Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Akhil BabyiD· 2 shared James W. McNamaraiD· 2 shared Sakthivel SadayappaniD· 2 shared Taejeong SongiD· 2 shared Aleksandra BinekiD· 1 shared Brent Cernyar· 1 shared Darshini A. Desai· 1 shared J.-P. Jin· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersPhysiology

Akhil BabyORCID

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2 papers

Recent·Most cited

Fast skeletal myosin binding protein-C expression exacerbates dysfunction in heart failure

James W. McNamara, Taejeong Song, Perwez Alam, Akhil Baby, Aleksandra Binek, Kalyani Ananthamohan, Rohit R. Singh, Michelle L. Nieman, Marloes van den Berg, Brent Cernyar, Sheryl E. Koch, Malina J. Ivey, Thomas L. Lynch, James T. Pearson, Jack Rubinstein, , Sakthivel Sadayappan

This study investigates the role of fast skeletal myosin binding protein-C in heart failure, finding that its expression exacerbates cardiac dysfunction and that its deletion improves heart function.

Basic Research in Cardiology · Aug 5, 2026Peer-reviewedPhysiology

MYBPC3 D389V Variant Induces Hypercontractility in Cardiac Organoids

Darshini A. Desai, Taejeong Song, Rohit R. Singh, Akhil Baby, James W. McNamara, Lisa C. Green, Pooneh Nabavizadeh, Mark B. Ericksen, Sholeh Bazrafshan, Sankar Natesan, Sakthivel Sadayappan

This study investigates the molecular mechanisms of HCM caused by the MYBPC3 D389V variant using cardiac organoids and shows hypercontractility and mitochondrial defects that are rescued by a myosin inhibitor.

Cells · Nov 19, 2024Peer-reviewedCell Biology