Development of noninvasive biomarkers of response to proteasome inhibitor therapy (ixazomib) by imaging disrupted protein homeostasis in mouse models of solid tumors
Yanan Zhu, Rajiv Ramasawmy, Sean Peter Johnson, Valerie Taylor, Alasdair Gibb, R Barbara Pedley, Nibedita Chattopadhyay, Mark F Lythgoe, Xavier Golay, Daniel Bradley, Simon Walker-Samuel
This study uses CEST MRI to noninvasively monitor proteasome inhibitor response in mouse tumor models, showing increased CEST signals with higher drug doses and varying tumor sensitivity.
bioRxiv · Sep 25, 2017 · PreprintBiophysics