Author

Mark R. Ambroso

Elements Biosciences (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1 Assay:scRNA-seq· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Andrew Altomare· 2 shared Bryan R. LajoieiD· 2 shared Matthew William Kellinger· 2 shared Semyon KruglyakiD· 2 shared Shawn LevyiD· 2 shared Vivian T. DieniD· 2 shared Adam Fries· 1 shared Adeline Mah· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Andrew Altomare

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2 papers

Recent·Most cited

Characterizing and addressing error modes to improve sequencing accuracy

Semyon Kruglyak, Andrew Altomare, Mark R. Ambroso, Vivian T. Dien, Bryan R. Lajoie, Kelly N. Wiseman, Shawn Levy, Matthew William Kellinger

The paper demonstrates achieving over 70% Q50 accuracy on the AVITI sequencer by improving sequencing quality and mitigating library preparation and analysis errors.

bioRxiv · Feb 1, 2024 · PreprintGenomics

Sequencing by avidity enables high accuracy with low reagent consumption

Sinan Arslan, Francisco J. Garcia, Minghao Guo, Matthew William Kellinger, Semyon Kruglyak, Jake A. LeVieux, Adeline Mah, Haosen Wang, Junhua Zhao, Chunhong Zhou, Andrew Altomare, John Bailey, Matthew B. Byrne, Chiting Chang, Steve X. Chen, , Jordan M. Neysmith

This paper introduces avidity sequencing, a new chemistry that improves sequencing accuracy and reduces reagent use, enabling applications like single-cell RNA-seq and whole-genome sequencing.

Nature Biotechnology · May 25, 2023Peer-reviewedGenomics