Author

Andrew Altomare

Elements Biosciences (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Matthew William Kellinger· 4 shared Semyon KruglyakiD· 4 shared Bryan R. LajoieiD· 3 shared Daniel J. HonigfortiD· 3 shared Mariam Dawood· 3 shared Sinan ArslaniD· 3 shared Vivian T. DieniD· 3 shared Adeline Mah· 2 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenomics

Matthew William Kellinger

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Direct In-Sample Sequencing of the 3' Transcriptome Expands the Capabilities of Optical Pooled Screens

Daniel J. Honigfort, Pedro Belda‐Ferre, David T. White, Kousik Sundararajan, Mariam Dawood, Jake A. LeVieux, Jacob Moreno, Xiaodong Qi, Kyle S. Metcalfe, Duuluu Naranbat, Andrew Altomare, Connor Thompson, Carlos Ruiz Perez, Bryan R. Lajoie, Hyuk-Jin Kwon, , Michael J. R. Previte

The paper introduces a platform that directly sequences 3'UTRs and guide RNAs in fixed cells alongside protein abundance and morphology, enabling CRISPR screening in lung cancer cells.

bioRxiv · Oct 11, 2025 · PreprintGenomics

High-Throughput Multiomics Profiling of Model Systems Using the AVITI24 Platform

Tyler Lopez, Daniel J. Honigfort, Adeline Mah, Connor Thompson, Vivian T. Dien, Mariam Dawood, Eva Frankel, Derek Fuller, Claudia Jamison, Ryan Kelley, Jean Kwon, Yu Liu, Pin Ren, Sanchari Saha, Haosen Wang, , Sinan Arslan

The paper introduces a multiomics platform for high-throughput analysis of cellular responses, demonstrating its ability to capture dynamic cellular processes and drug responses in cancer cells.

bioRxiv · May 3, 2025 · PreprintGenomics

Characterizing and addressing error modes to improve sequencing accuracy

Semyon Kruglyak, Andrew Altomare, Mark R. Ambroso, Vivian T. Dien, Bryan R. Lajoie, Kelly N. Wiseman, Shawn Levy, Matthew William Kellinger

The paper demonstrates achieving over 70% Q50 accuracy on the AVITI sequencer by improving sequencing quality and mitigating library preparation and analysis errors.

bioRxiv · Feb 1, 2024 · PreprintGenomics

Sequencing by avidity enables high accuracy with low reagent consumption

Sinan Arslan, Francisco J. Garcia, Minghao Guo, Matthew William Kellinger, Semyon Kruglyak, Jake A. LeVieux, Adeline Mah, Haosen Wang, Junhua Zhao, Chunhong Zhou, Andrew Altomare, John Bailey, Matthew B. Byrne, Chiting Chang, Steve X. Chen, , Jordan M. Neysmith

This paper introduces avidity sequencing, a new chemistry that improves sequencing accuracy and reduces reagent use, enabling applications like single-cell RNA-seq and whole-genome sequencing.

Nature Biotechnology · May 25, 2023Peer-reviewedGenomics