Matthew William Kellinger

Cytos MPS: an automated multimodal pooled screening platform for protein, morphology and transcriptomics

Cytos MPS integrates CRISPR guide identity, morphology, transcriptomics, and protein data to reveal multimodal phenotypes from perturbations.

Direct In-Sample Sequencing of the 3' Transcriptome Expands the Capabilities of Optical Pooled Screens

The paper introduces a platform that directly sequences 3'UTRs and guide RNAs in fixed cells alongside protein abundance and morphology, enabling CRISPR screening in lung cancer cells.

Unraveling Tyrosine-Kinase Inhibitor Resistance in NSCLC Cells via Same-cell Measurement of RNA, Protein, and Morphological Responses

The paper measures RNA, protein, and morphology in NSCLC cells treated with TKIs to identify resistance mechanisms and show that CDK4/6 inhibition enhances TKI efficacy.

High-Throughput Multiomics Profiling of Model Systems Using the AVITI24 Platform

The paper introduces a multiomics platform for high-throughput analysis of cellular responses, demonstrating its ability to capture dynamic cellular processes and drug responses in cancer cells.

Characterizing and addressing error modes to improve sequencing accuracy

The paper demonstrates achieving over 70% Q50 accuracy on the AVITI sequencer by improving sequencing quality and mitigating library preparation and analysis errors.

Sequencing by avidity enables high accuracy with low reagent consumption

This paper introduces avidity sequencing, a new chemistry that improves sequencing accuracy and reduces reagent use, enabling applications like single-cell RNA-seq and whole-genome sequencing.