Modulation of RNA-dependent interactions in stress granules prevents persistent TDP-43 accumulation in ALS/FTD
Mark Y. Fang, Sebastian Markmiller, Anthony Q. Vu, Ashkan Javaherian, William E. Dowdle, Philippe Jolivet, Paul Bushway, Nicholas A. Castello, Ashmita Baral, Michelle Y. Chan, Jeremy W. Linsley, Drew A. Linsley, Mark A. Mercola, Steven M. Finkbeiner, Éric Lécuyer, , Gene Wei-Ming Yeo
The paper introduces VariantKey, a reversible numerical encoding for genetic variants, and presents compounds that inhibit stress granule formation and TDP-43 accumulation in ALS/FTD models.
Neuron · Jul 1, 2019Peer-reviewedNeuroscience