Éric Lécuyer

Integrating SHAPE Probing with Direct RNA Nanopore Sequencing Reveals Dynamic RNA Structural Landscapes

The paper introduces Dashing Turtle (DT), an algorithm for high-resolution detection of RNA structural modifications using direct RNA nanopore sequencing, showing improved accuracy over existing methods.

Comparative profiling of SARS-CoV-2 variant infections reveals diverse impacts on host cell RNA and RNA binding protein distribution and regulation

This study compares the impact of SARS-CoV-2 variants on host cell RNA and RNA binding protein distribution, finding Omicron causes less disruption and maintains higher expression of translation factors.

Investigating the Impacts of Sphingomyelinases on Extracellular Vesicle Cargo Sorting

This study investigates how inhibiting sphingomyelinases affects extracellular vesicle cargo sorting in human cells, revealing distinct impacts on RNA and protein content and cellular behavior.

Localized translation of cell junction mRNAs is required for epithelial cell polarity

The paper shows that localized mRNA translation at cell junctions is essential for epithelial cell polarity, with MAGOH and ZO-1 linked to good prognosis in ovarian cancer.

A Large-Scale Binding and Functional Map of Human RNA Binding Proteins

The paper maps and characterizes RNA elements recognized by human RNA binding proteins in K562 and HepG2 cells, expanding the catalog of functional elements in the human genome.

Staufen1 localizes to the mitotic spindle and controls the transport of RNA populations to the spindle

The paper shows Staufen1 localizes to the mitotic spindle and transports specific RNAs, including pre-rRNA and mRNAs, to the spindle, affecting cell division processes.

Modulation of RNA-dependent interactions in stress granules prevents persistent TDP-43 accumulation in ALS/FTD

The paper introduces VariantKey, a reversible numerical encoding for genetic variants, and presents compounds that inhibit stress granule formation and TDP-43 accumulation in ALS/FTD models.

Drosophila ribosomal protein S5b is essential for oogenesis and interacts with distinct RNAs

This study shows that RpS5b is essential for oogenesis in Drosophila and interacts with mRNAs related to mitochondrial function.