Author

Michelle Y. Chan

Gladstone InstitutesORCID 0000-0002-9105-9977Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Ashkan JavaherianiD· 2 shared Jeremy W. LinsleyiD· 2 shared Nicholas A. Castello· 2 shared Steven M. FinkbeineriD· 2 shared Anthony Q. VuiD· 1 shared Ashmita Baral· 1 shared David KokeliD· 1 shared Dominik HaddadiD· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersNeuroscience

Ashkan JavaherianORCID

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2 papers

Recent·Most cited

Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration

Jeremy W. Linsley, Kevan D. Shah, Nicholas A. Castello, Michelle Y. Chan, Dominik Haddad, Zak Doric, Shijie Wang, Wiktoria Leks, Jay Mancini, Viral D. Oza, Ashkan Javaherian, Ken Nakamura, David Kokel, Steven M. Finkbeiner

This paper introduces GEDI, a fluorescent biosensor that detects early irreversible commitment to cell death in neurons, enabling real-time and high-throughput analysis of neurodegeneration.

Nature Communications · Sep 6, 2021Peer-reviewedNeuroscience

Modulation of RNA-dependent interactions in stress granules prevents persistent TDP-43 accumulation in ALS/FTD

Mark Y. Fang, Sebastian Markmiller, Anthony Q. Vu, Ashkan Javaherian, William E. Dowdle, Philippe Jolivet, Paul Bushway, Nicholas A. Castello, Ashmita Baral, Michelle Y. Chan, Jeremy W. Linsley, Drew A. Linsley, Mark A. Mercola, Steven M. Finkbeiner, Éric Lécuyer, , Gene Wei-Ming Yeo

The paper introduces VariantKey, a reversible numerical encoding for genetic variants, and presents compounds that inhibit stress granule formation and TDP-43 accumulation in ALS/FTD models.

Neuron · Jul 1, 2019Peer-reviewedNeuroscience