Author

Nicholas A. Castello

Gladstone Institutes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1

Frequent Co-Authors

Ashkan JavaherianiD· 3 shared Steven M. FinkbeineriD· 3 shared Ashmita Baral· 2 shared Jeremy W. LinsleyiD· 2 shared Michelle Y. ChaniD· 2 shared Aaron D. GitleriD· 1 shared Alice Flynn Ford· 1 shared Anthony Q. VuiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersNeuroscience

Ashkan JavaherianORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Opposing roles of p38α phosphorylation and arginine methylation in driving TDP-43 proteinopathy.

Mari Aikio, Hana M. Odeh, Heike J. Wobst, Bo Lim Lee, Úna Chan, Jocelyn C. Mauna, Korrie L. Mack, Bradley Class, Thomas A. Ollerhead, Alice Flynn Ford, Edward M. Barbieri, Ryan R. Cupo, Lauren E. Drake, Joshua L. Smalley, Yuan-Ta Lin, , James Shorter

This study identifies opposing roles of p38α phosphorylation and arginine methylation in TDP-43 proteinopathy, showing that phosphorylation promotes aggregation while methylation reduces it.

Cell Reports · Jan 1, 2025Peer-reviewedMolecular Biology

Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration

Jeremy W. Linsley, Kevan D. Shah, Nicholas A. Castello, Michelle Y. Chan, Dominik Haddad, Zak Doric, Shijie Wang, Wiktoria Leks, Jay Mancini, Viral D. Oza, Ashkan Javaherian, Ken Nakamura, David Kokel, Steven M. Finkbeiner

This paper introduces GEDI, a fluorescent biosensor that detects early irreversible commitment to cell death in neurons, enabling real-time and high-throughput analysis of neurodegeneration.

Nature Communications · Sep 6, 2021Peer-reviewedNeuroscience

Modulation of RNA-dependent interactions in stress granules prevents persistent TDP-43 accumulation in ALS/FTD

Mark Y. Fang, Sebastian Markmiller, Anthony Q. Vu, Ashkan Javaherian, William E. Dowdle, Philippe Jolivet, Paul Bushway, Nicholas A. Castello, Ashmita Baral, Michelle Y. Chan, Jeremy W. Linsley, Drew A. Linsley, Mark A. Mercola, Steven M. Finkbeiner, Éric Lécuyer, , Gene Wei-Ming Yeo

The paper introduces VariantKey, a reversible numerical encoding for genetic variants, and presents compounds that inhibit stress granule formation and TDP-43 accumulation in ALS/FTD models.

Neuron · Jul 1, 2019Peer-reviewedNeuroscience