Jeremy W. Linsley

This study uses a dynamic in vitro model to correct Trisomy 21 gene dosage in DS neurogenesis and shows XIST can suppress chr21 genes even after terminal differentiation.

The paper develops a deep learning platform to screen compounds for ALS treatment using age-relevant human motor neurons and identifies NCB-0846 as a potential therapeutic.

This study identifies stac1 in zebrafish embryos and shows it is required for sensory stimulus-induced escape locomotion via regulation of CSF-cNs.

This paper introduces GEDI, a fluorescent biosensor that detects early irreversible commitment to cell death in neurons, enabling real-time and high-throughput analysis of neurodegeneration.

This paper introduces a cell tracking method based on Voronoi partition and stable matching to improve tracking accuracy from coarsely sampled live-cell imaging data.

The paper introduces VariantKey, a reversible numerical encoding for genetic variants, and presents compounds that inhibit stress granule formation and TDP-43 accumulation in ALS/FTD models.