Mitochondrial cardiolipin metabolism controlled by tafazzin enables ferroptosis
Yvonne Wohlfarter, Judith Hagenbuchner, Utku Horzum, Gregor Oemer, Andreas Winter, Markus Seifert, Julian Schwärzler, Janik Kokot, Pablo Hernansanz‐Agustín, Viktorija Jurić, Luiz Felipe Garcia Suoza, Heribert Talasz, José Antonio Enríquez Domínguez, Hesso Farhan, Timon E. Adolph, , Markus Andreas Keller
The paper shows that tafazzin deficiency in Barth Syndrome protects against ferroptosis by altering mitochondrial cardiolipin metabolism, affecting VDAC function and reducing ROS availability for ferroptosis.
bioRxiv · Oct 25, 2024 · PreprintMolecular Biology