Presynapses are mitophagy pit stops that prevent axon degeneration
Wai Kit Lam, Runa S. J. Lindblom, Bridget Milky, Paris Mazzachi, Marjan Hadian-Jazi, Catharina J. Küng, Grace Khuu, Louise Uoselis, Thanh Ngoc Nguyen, Marvin Skulsuppaisarn, Tahnee L. Saunders, Marlene F. Schmidt, Grant Dewson, Adam I. Fogel, Cédric Bardy, Michael Lazarou
The paper identifies presynapses as sites of mitophagy in neurons and shows their role in preventing axon degeneration when mitophagy is defective.
bioRxiv · Sep 9, 2024 · PreprintCell Biology