Airway basal stem cells are necessary for the maintenance of functional intraepithelial airway macrophages.
Tristan Kooistra, Borja Sáez, Marly I. Roche, Alejandro Egea-Zorrilla, Dongzhu Li, Dilanjan Anketell, Nhan Nguyen, Jorge Villoria, Jacob E. Gillis, Eva Petri, Laura Vera, Zuriñe Blasco‐Iturri, Neal Patrick Smith, Jehan W. Alladina, Yan-ting Yann Zhang, , Ana Pardo–Saganta
This study shows that airway basal stem cells maintain intraepithelial airway macrophages via Notch signaling, enabling localized allergic inflammation in the trachea but not distal lung tissues.
Cell Reports · Jun 1, 2025Peer-reviewedCell Biology