Benjamin D. Medoff

Distinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma

This study compares T cell phenotypes and clonotypes from bronchoalveolar lavage and endobronchial brushings in healthy controls and allergic asthmatics, finding distinct transcriptional and TCR repertoire features.

Airway basal stem cells are necessary for the maintenance of functional intraepithelial airway macrophages.

This study shows that airway basal stem cells maintain intraepithelial airway macrophages via Notch signaling, enabling localized allergic inflammation in the trachea but not distal lung tissues.