Tumor-to-endothelium mitochondrial transfer licenses endothelial cells for CD8+ T cell recognition via mitochondrial neoantigen presentation
Francesca Costabile, Stefano Pierini, Renzo F. Perales-Linares, Nektaria Maria Leli, Adham Sean Bear, Cameron J. Koch, Beatriz M. Carreno, M T Lotze, Larry N. Singh, Marny Falck, Andrea Facciabene
This study shows that vaccinating against tumor-associated mitochondrial antigens enhances CD8+ T cell recognition of endothelial cells, improving immune response and survival in RCC models.
bioRxiv · Feb 2, 2026 · PreprintCancer Biology