Cancer BiologybioRxivPreprint
Tumor-to-endothelium mitochondrial transfer licenses endothelial cells for CD8+ T cell recognition via mitochondrial neoantigen presentation
Francesca Costabile, Stefano Pierini, Renzo F. Perales-Linares…·Andrea Facciabene
This study shows that vaccinating against tumor-associated mitochondrial antigens enhances CD8+ T cell recognition of endothelial cells, improving immune response and survival in RCC models.