Michael T. Lotze

This study shows that chronic inflammation and hormonal changes in older women create a tumor-permissive environment for ER+ breast cancer by increasing local estradiol and immune dysfunction.

This study shows that vaccinating against tumor-associated mitochondrial antigens enhances CD8+ T cell recognition of endothelial cells, improving immune response and survival in RCC models.

The paper develops a computational model of pancreatic cancer signaling and mutations to identify potential inhibitor combinations for therapy.