Regulatory elements of pancreas development license the initiation of pancreatic ductal adenocarcinoma
Marta Ballester, Anita Kurilla, Yifan Dai, H. Carlo Maurer, Elisa Espinet, Kristina Høj, Aida Marisch Delgado, Philip Allan Seymour, Saynab Omar, Charlotte Vestrup Rift, Jane Preuss Hasselby, Pia Helene Klausen, Peter Vilmann, Albin Sandelin, Luís Arnes
This study identifies LINC00673, a long noncoding RNA from a Sox9-associated super-enhancer, as critical for pancreatic regeneration and PDAC initiation by regulating cell-autonomous and non-cell-autonomous processes.
bioRxiv · Jun 6, 2025 · PreprintCell Biology